Genetic Testing

  
 

If you have a family history of chromosome problems, we can offer pre-implantation genetic testing of embryos to detect any inherited abnormalities. There are two options available:

Pre-implantation Genetic Screening

Pre-implantation genetic screening (PGS) involves detection of any numerical chromosome abnormalities in the embryo before its transfer to the uterus during an IVF / ICSI treatment. This process avoids the transfer of abnormal embryos to the womb. Chromosome abnormalities can cause failure of embryos to implant (causing repeated unsuccessful cycles of IVF) and recurrent miscarriage.

There has been recent enhancements to this technique via the use of Comparative Genomic Hybridisation (CGH), which has made possible the screening of all 23 pairs of chromosomes within an embryo.

Pre-implantation Genetic Diagnosis

Pre-implantation genetic diagnosis (PGD) is a technique aimed at couples with a specific inherited condition who wish to avoid passing it to their children. This procedure involves checking the genes of embryos created during an IVF / ICSI treatment for this genetic condition before transfer to the womb.

The list of genetic conditions acceptable by HFEA to test for using PGD is available here.

Chromosome abnormalities such as aneuploidy (extra or missing chromosomes), translocations, inversion, insertion or ring chromosomes are responsible for a large portion of genetic diseases. Single gene disorders can also be transmitted from parents to their offspring. Using PGD, these structural chromosome abnormalities and single gene disorders can be detected in the embryo before its transfer to the uterus.

Note

Genetic testing is offered at The Fertility & Gynaecology Academy in association with Boston Place Clinic, 20 Boston Place, London, NW1 6ER.